Category Archives: thermal management

Case Study: High-Powered Altera Stratix 10 FPGAs

Altera Stratix 10 FPGAs`

Advanced Thermal Solutions, Inc. engineers designed a solution to cool a board that contained high-powered Altera Stratix 10 FPGAs. (Advanced Thermal Solutions, Inc.)


Engineers at Advanced Thermal Solutions, Inc. were asked to test the layout of a PCB that was using Altera Stratix 10 FPGAs (field-programmable gate arrays) with fans on one side pulling air across the board. The client used ATS heat sinks on the original iteration of the PCB and wanted to ensure those heat sinks would provide the necessary cooling for this iteration as well.

Through a combination of analytical modeling and CFD simulations, ATS engineers determined that the heat sinks already being used would provide enough cooling for the more powerful components.

• Challenge: ATS conducted thermal analysis of a system with Altera Stratix 10 FPGA units when using ATS 1634-C2-R1 and ATS FPX06006025-C1-R0 heat sinks. Two of the FPGAs would be running at 90 watts and one at 40 watts and there were fans on one side of the PCB that would pull air across the board.

• Chip/Component: Altera Stratix 10 FPGAs

• Analysis: Analytical models and CFD simulations were run with ATS 1634-C2-R1 heat sinks and several other options, including copper and aluminum heat sinks with and without embedded heat pipes. CFD simulations also created fan curves for all six of the Mechtronics MD4028V fans being used.

• Test Data: The data showed that even with the additional power of the new chips that the original heat sinks would keep the case temperature below 80°C. The other heat sinks showed similar case temperatures mostly below 80°C as well. Fan curves showed that the fans were operating near the knee, which the client was notified about.

• Solution: ATS engineers recommended staying with the ATS 1634-C2-R1 heat sink because it was able to cool the high-powered FPGAs below the maximum case temperature. The ATS FPX06006025-C1-R0 was recommended for the lower power FPGA.

Altera Stratix 10 FPGAs

CFD simulation with the case temperatures of the three FPGA using the original ATS heat sinks.
(Advanced Thermal Solutions, Inc.)

• Net Result: The customer was able to continue using the same heat sinks that had worked on the prior iteration of the PCB.

For more information about Advanced Thermal Solutions, Inc. thermal management consulting and design services, visit www.qats.com or contact ATS at 781.769.2800 or [email protected].

Industry Developments: Cooling Solar Power Inverters

By Norman Quesnel, Senior Member of Marketing Staff
Advanced Thermal Solutions, Inc.

(This article will be featured in an upcoming issue of Qpedia Thermal e-Magazine, an online publication dedicated to the thermal management of electronics. To get the current issue or to look through the archives, visit http://www.qats.com/Qpedia-Thermal-eMagazine.)

Traveling across the U.S. one will find the widening use of renewable energy systems, including large scale solar and wind farms. The power from these installations is clean, emission-free and relatively low cost. Their own energy sources are free and endless: the wind and the sun.

Wind energy has become a cost-effective power source, competing with installations of coal, gas and nuclear power. So too has solar power, which is the focus of this article.

Solar power is doing more than ever to help meet energy demands for local power and for feeding power back to the electric grid. Today’s U.S. solar installations exceed 3,100 megawatts, enough to power more than 630,000 homes. The price of solar panels has dropped by nearly a third since 2010 and costs continue to fall. Manufacturers in the U.S. are also exporting billions of dollars worth of solar products. [1]

Figure 1. Wind and Solar Power Installations Share Some Thermal Management Issues with Other Electronics Systems. [2]

Most thermal management issues in solar power systems occur with their inverter systems. Here, the solar-generated DC power is converted to AC for power grids or local use. While these inverter systems can be very efficient, some excess heat must be managed so it doesn’t affect the inverter’s life or performance.

Cooling Solar Energy Inverters

Some solar power systems produce steam to spin turbines and generate electricity. But the more common solar systems are photovoltaic (PV) solar power facilities. In these, solar panels absorb and convert sunlight into electricity with the use of inverters. One or more solar inverters, or PV inverters, converts the sun-sourced, variable DC output of the PV panels into alternating current, AC. This is then fed into a commercial electrical grid or used by a local, off-grid electrical network. AC is the standard used by all commercial appliances, which is why many view inverters as the gateway between the photovoltaic (PV) system and the energy off-taker. [3]

Inverters are standard in PV solar systems whether they’re kW range residential systems to MW sized power plants. Larger installations may use a central inverter or a series of string inverters.

In a central inverter set up, the DC power from multiple solar panel arrays runs to combiner boxes and then to the inverter which converts it to AC. In a string inverter scheme, there are smaller, individual inverters for several panel arrays. The DC power runs directly into a string inverter rather than a combiner box and is converted to AC. While string inverters are used in residential to medium-sized commercial PV systems, central inverters are common to large commercial and utility-scale sites. [4]

Solar Power Inverters

Figure 2. Photovoltaic Solar Panel Installations Can Feature a Central Inverter or a Series of String Inverters. [4]

There are also solar microinverters that convert the DC generated by a single solar module to AC. The output from several microinverters is combined and often fed to the electrical grid. Microinverters are an alternative to conventional string and central solar inverters, which are connected to multiple solar modules or panels of the PV system. The main advantage of microinverters is that small amounts of shading, debris or snow on any one solar module, or even a complete module failure, do not disproportionately reduce the output of the entire array. [5]

Whatever its configuration, the PV inverter determines the amount of AC watts that can be distributed for use, e.g. to a power grid. For example, a PV system comprising 11 kilowatts DC (kWDC) worth of PV modules, connected to a 10-kilowatt AC (kWAC) inverter, will be limited to the inverter’s maximum output of 10 kW. [6]

There is also some power loss in the DC-AC conversion process. At the MW scale this could significantly impact a plant’s capacity (and revenue). But fortunately, inverter technologies have been advancing and expanding. The efficiency of state-of-the-art converters is more than 98 percent.

In addition to converting DC to AC, today’s inverters provide other services to help ensure their systems operate at optimal performance level. These include data monitoring, advanced utility controls, applications and system design engineering. Some inverters provide maximum power point tracking (to maximize power extraction), and anti-islanding protection (automatic shutdown). [7]

Cooling PV Solar Inverters

All inverters generate excess heat, especially utility-scale central inverters. Solar inverters used in the kW range are typically contained in finned metal housings that provide cooling via natural convection. Large-scale PV inverters are typically between 1 and 2 MW and the heat they generate directly correlates with their conversion efficiency. For an example, a 1 MW inverter with 98 percent conversion efficiency is generating about 20 kW of thermal energy. This is enough heat to comfortably warm 10 homes. [8]

Cooling solutions are typically needed inside inverters to protect their IGBT (insulated-gate bipolar transistors) modules. These solid state power semiconductor devices are electronic switches and consist of many devices in parallel. The design of the IGBTs and their cooling systems are among the most important aspects in protecting inverters and improving their conversion efficiency.

Improper IGBT design results in lower efficiency with higher heat exhaust. Cooling this heat requires a more complex and powerful cooling system. Better thermal management for the switching devices is essential to entering the next era of PV inverter efficiency, beyond 99 percent.

The recently-introduced PVS980 1500 VDC outdoor central inverter by ABB is optimized for large multi-megawatt solar power plants. The PVS980 features a self-contained cooling system to ensure outstanding endurance in tough environments with minimal maintenance. The cooling system uses phase transition and thermosiphon technology to prevent external air from entering the critical compartments of the inverter. This reduces the risk of corrosive gases or sand entering the inverter and causing damage. [9]

Solar Power Inverters

Figure 3. The Cooling System in ABB’s PVS980 Outdoor Central Inverter Uses Phase Transition and Thermosiphon Technology. [9]

The PVS980 inverter can operate from below freezing to extreme heat in 100 percent humidity without jeopardizing functionality. With the simplicity of air cooling and with the power density of a liquid cooled inverter, ABB’s inverter has very high total efficiency and low maintenance. There are no fillable liquids, pumps, valves, inhibitors and thus no leaks. All this makes the PVS980 suitable for any outdoor utility-scale PV plant.

Solar Power Inverters

Figure 4. The LV 5 Series Solar Inverter from GE Power Conversion Features a Liquid Cooling System. [10]

Some of the recent advancement in the inverter cooling system, such as an advanced hybrid cooling solution, requires significantly less air-flow in the system without an auxiliary fan power load. This lower load condition allows the inverter to further increase conversion efficiency. [11]

Solar Power Inverters

Figure 5. Outdoor Central Solar Inverter Whose Power Semiconductors, Inductor and Internal Ambient Air are Cooled by a Two-Phase System. [10]

Parker provides utility scale inverters with two-phase refrigerant cooling systems. The have a high efficiency design that integrates proven insulated gate bipolar transistor power conversion and magnetics with Parker cooling technology. No air conditioner is required. Power semiconductors, inductor, and internal ambient are all cooled by the integral two-phase system. Multiple access panels simplify installation and scheduled maintenance. [11]

The small footprint and high reliability of Parker’s outdoor central solar inverter is made possible by an advanced cooling system that uses a non-conductive, non-corrosive liquid to cool critical components. The refrigerant requires only 13 percent of the flow rate of an equivalent water/glycol based system. The cooling system runs efficiently by capitalizing on the tremendous amount of heat that is transferred as the refrigerant vaporizes, then releasing the heat through a condenser. No compressor is needed. Redundant system components allow inverter operation even after loss of a pump or a fan

Solar Power Inverters

Figure 6. IGBTs Mounted on a Cold Plate Inside a Central Solar Inverter. [11]

Compared to air cooling, with Parker’s solar inverter design IGBT temperatures are kept more constant over time. Advanced cooling is used on both the IGBT devices and the high efficiency inductors, as well as with a unique cool door feature that circulates temperature controlled air inside the sealed enclosure. Heat from the coolant loop is removed by an isolated heat exchanger, with no air exchange from the enclosure interior to the outside environment. Heat exchanger fans are variable speed for maximum efficiency. They are designed for redundancy and are monitored for rotation. In the event of a fan or coolant pump malfunction, the inverter will continue to operate, folding back power if necessary. The cooling system is designed for a minimum of maintenance, and there are no air filters to change.

Solar Power Inverters

Figure 7. Fan-less Heat Pipe Cooling is Used Up to 50% Load in This Toshiba 1500VDC PV Inverter. [12]

Another producer of large scale PV inverters is TMEIC (Toshiba Mitsubishi-Electric Industrial Systems Corporation). Their Samurai inverter series has power ratings up to 2700 kW. Each model has an advanced hybrid cooling system that uses heat pipe technology. The heat pipes allow the system to operate up to 50 percent load without turning on fans. The heat pipe cooling uses fewer parts and a slow speed fan. The fan-less mode runs when the inverter is below 50 percent load at 50°C. Natural convection provides the necessary cooling. Cool air enters from the bottom, flows through the heat pip, and hot air is exhausted from the top. [12]

Conclusion

A PV solar power system’s current inverter determines the amount of AC watts that can be distributed for use, e.g. to a power grid. For systems operating in the megawatt output range, the inverters will require some level of thermal management to cool their IGBT systems. Many of these large inverter systems have custom cooling solutions that can differ from each other (e.g. air cooling vs. liquid cooling) but all methods have their origins in cooling electronics other than those found in the solar power industry.

References
[1] http://www.cleanlineenergy.com/technology/wind-and-solar
[2] Photo by American Public Power Association on Unsplash
[3] http://www.solarpowerworldonline.com/2013/04/how-do-solar-inverters-work/
[4] http://cenergypower.com/blog/string-vs-central-inverters-choosing-right-inverter/
[5] https://en.wikipedia.org/wiki/Solar_micro-inverter
[6] http://www.solarmango.com/scp/solar-inverter-the-brain-of-a-solar-power-plant/
[7] https://en.wikipedia.org/wiki/Photovoltaic_system
[8] http://www.solarpowerworldonline.com/2015/02/new-age-solar-inverter-conversion-efficiency-99/
[9] http://www.abb.com/cawp/seitp202/db94b0aa1e8655a9c1257fdb0043680e.aspx
[10] http://www.gepowerconversion.com/sites/gepc/files/downloads/Solar_Single_Pages.pdf
[11] http://www.parker.com/literature/Renewable%20Energy/Parker_RenewablesBrochure__NA_7-2_spreads_lr.pdf
[12] https://www.tmeic.com/Repository/Others/Solar_Ware_Samurai_brochure_Rev-T-July2016.pdf

ATS holding webinar on Thermal Management of Medical Electronics

Medical Webinar

DR. Kaveh Azar, founder, CEO and President of Advanced Thermal Solutions, Inc. (ATS), will present a free webinar on “Thermal Management in Medical Electronics” on Dec. 15, 2016.

On Thursday, Jan. 26, Advanced Thermal Solutions, Inc. (ATS) will host a free, online webinar on “Thermal Management of Medical Electronics”. The hour-long webinar will begin at 2:00 p.m. and there will be 30 minutes of question and answer time after its completion.

The webinar will be presented by thermal management expert Dr. Kaveh Azar, the CEO, President and founder of ATS. Dr. Azar will speak about the unique challenges that are present in finding a thermal solution for medical electronics and the importance of including thermal management in the design process.

The object of all thermal management is to ensure that the device junction temperature, the hottest point on a semiconductor, stays below a set limit. While this is true for all electronic systems, medical electronics pose unique thermal challenges that have to be overcome to meet the junction temperature requirements.

Medical electronics could have stringent material selection. For example, copper is a common metal chosen in thermal management, but can cause irritation or a neurodegenerative condition for patients and has to be used carefully. In addition, medical electronics may have spatial constraints, such as forceps that have only 2-4 millimeters of width, which is a constrained space with very little airflow.

Other challenges presented by medical electronics include the need for constant, reliable repeatability; temperature reliability within a range; and in some cases specific FDA requirements.

Dr. Azar will address each of these issues and more. To register for the free webinar on Thursday, Jan. 26, visit http://www.qats.com/Training/Webinars.

Industry Developments: Cooling Nuclear Power Plants

By Norman Quesnel, Senior Member of Marketing Staff
Advanced Thermal Solutions, Inc.

(This article will be featured in an upcoming issue of Qpedia Thermal e-Magazine, an online publication dedicated to the thermal management of electronics. To get the current issue or to look through the archives, visit http://www.qats.com/Qpedia-Thermal-eMagazine.)

Most man-made electricity in the U.S. is provided by thermoelectric power plants. In these large scale installations, water is boiled to steam to spin the plant’s turbines and to ultimately generate electricity. To provide the heat necessary to produce this steam, a power plant could burn coal, natural gas or oil. But, in fact, most plants don’t burn anything. Instead, they use a very hot, but carefully controlled core of nuclear material to provide the thermal energy for continuous steam.

Most large power plants use pressurized water reactors (PWRs) with nuclear fuel as their power source. There are different cooling requirements inside these plants and they are typically achieved with primary, secondary and tertiary thermal solutions. First, heat must be managed inside their reactor vessels where the radioactive material is housed. Then, in the steam generators, hot water from the reactor vessels is cooled by transferring its heat to a separated water source, converting it to steam. Lastly, after the steam moves past the turbines, it is condensed back to liquid water, which then returns to the steam generator. An illustration of a nuclear power plant with a pressurized water reactor is shown in Figure 1. [1]

Nuclear  Power Plant

Figure 1. Components of a Pressurized Water Reactor in a Nuclear Power Plant. [2]

Inside a PWR’s reactor core, the primary coolant, usually ordinary water, is heated by energy from atomic fission. Under high pressure to keep it from boiling, the heated water flows along a primary, closed-loop piping system into a steam generator. Here, the heat from the primary loop transfers into an isolated, lower-pressure secondary loop also containing water.

The water in the secondary loop enters the steam generator at a pressure and temperature slightly below that required to initiate boiling. Upon absorbing heat from the primary loop, it becomes saturated and slightly super-heated. The water changes phase to steam, which serves as the working fluid to push the turbine blades and generate electricity.

Finally, the steam is condensed back to water and re-enters the secondary loop. There are different ways to provide this tertiary level of cooling to cause this condensation. [3]

Fueling a Nuclear Reactor

A nuclear power plant’s reactor is most often fueled by U-235, a type of uranium that fissions easily. U-235 is a component of uranium hexafluoride fuel, which is made from mined or milled uranium oxide, called yellowcake. To make the uranium hexafluoride usable as a fuel, it is enriched to increase its U-235 content from 1 percent up to 3-5 percent. This is a low concentration and the enriched uranium is stable over a wide range of environmental conditions.

After the uranium hexafluoride is enriched, a fuel fabricator converts it into uranium dioxide powder and presses the powder into solid fuel pellets. The fabricator loads the ceramic pellets into long, pencil-thin rods made of a noncorrosive material, usually a zirconium alloy. These tubes, each about 4 meters long, are grouped by the hundreds into bundles that are called fuel assemblies. [4]

Figure 2. A Pressurized Water Reactor Includes Inlets and Outlets for Passing Water Coolant. [5]

A single fuel rod assembly for a pressurized water reactor (PWR) is approximately 13 feet high and weighs about 1,450 pounds. [6]

Step 1. Cooling the Nuclear Core

During a nuclear fission chain reaction, fuel rods heat up to about 800°C. If they are left uncovered by water, they’ll reach temperatures well about 1,000°C and begin to oxidize. That oxidation will react with any water that remains in the vicinity, producing highly explosive hydrogen gas. So, fuel rods are kept submerged in demineralized water, which serves as the primary coolant. The water is kept in a pressurized containment vessel and reaches about 325°C. [7]

At the atomic level, continuous exothermic fission in the fuel rods releases heat into the water in the PWC’s reactor. Nuclear power plants manage this fission and its resulting heat with the use of control rods. The rate of fission can be controlled–even stopped–by inserting and removing the control rods in the reactor. The control rods are made with neutron-absorbing material such as cadmium, hafnium or boron. Their presence controls the rate of nuclear reaction by absorbing neutrons, which otherwise would contribute to the fission chain reaction.

Figure 3. Control Rods Manage the Fission Rate Inside Nuclear Reactor Cores.

A single uranium fuel pellet the size of a fingertip contains as much energy as 17,000 cubic feet of natural gas or 1,780 pounds of coal. This relatively clean energy property, along with its vast half-life (700 million years), makes U-235 a viable alternative to burning fossil fuels to turn power plant turbines. [6]

Control Rod Drive Mechanisms (CRDMs) lower, raise, and keep in position assemblies of control rods inside a nuclear reactor. The rods absorb free neutrons, limiting the number available to cause fission of nuclear fuel. [8]

Step 2: Heat Transfer in Steam Generators

In a PWC-style nuclear power plant, the primary coolant, carrying heat from the reactor core, flows through a looped system into and out of a steam generator. Inside the generator it transfers its heat to an isolated, secondary coolant, water, converting it to steam. This steam travels in a secondary loop to the turbines. The transfer of heat from the primary loop to the secondary loop is accomplished without mixing the two fluids to prevent the secondary coolant from becoming radioactive.

Figure 4. Illustration of a Steam Generator. [9]

Figure 4. Illustration of a Steam Generator. [9]

There are multiple generators in a nuclear power plant. Each can measure up to 70 feet in height and weigh as much as 800 tons. A generator has more than 10,000 tubes, adding up to hundreds of miles in total length. A steam generator’s tubes are in a U-shape formation and each tube is about 19mm in diameter. Coolant from the reactor enters the generator’s inlet nozzle and circulates through the U-tubes.

The secondary coolant flows upward by natural convection through the bundle absorbing heat from the tubes of primary coolant. As heat is transferred through the tube walls, the secondary coolant, water, is turned into steam that flows from the top of the generator.

The materials that make up the steam generators and tubes are specially made and specifically designed to withstand heat, thermal expansion, high pressure, corrosion and radiation. The tubes are an important barrier between the radioactive and non-radioactive sides of the plant. For this reason, the integrity of the tubing is essential in minimizing the leakage of water between the two sides. [9]

Figure 5.  Steam Generator Tubes Transfer Heat from the Primary to the Secondary Loop. [8]

Figure 5. Steam Generator Tubes Transfer Heat from the Primary to the Secondary Loop. [8]

Step Three: Condensing the Steam

Once the steam has passed through a turbine, it must be cooled back into water by a third process and returned to the steam generator to be heated once.

Figure 6. Simple Illustration of Recirculation Scheme for Power Plant Steam. [10]

Figure 6. Simple Illustration of Recirculation Scheme for Power Plant Steam. [10]

There are three main methods of cooling a power plant’s steam and residual hot water:

Once-through systems take water from nearby sources (rivers, lakes, oceans), circulate it through condensers, and discharge the now warmer water to the local source. Once-through systems were initially popular because of their simplicity, low cost, and the abundant supplies of cooling water. But these systems can cause disruptions to local ecosystems, mainly from the large water withdrawals.

Wet recirculating systems reuse cooling water in a second cycle rather than immediately discharging it back to the original water source. Typically, wet recirculating systems use cooling towers to expose water to ambient air. Some water evaporates, but the rest is sent back to the condenser in the power plant. Because wet-recirculating systems only withdraw water to replace what’s lost through evaporation, these systems have much lower water withdrawals than once-through systems. Before being fed into the steam generator, the condensed steam (referred to as feed water) is sometimes preheated in order to minimize thermal shock.

More recently, plants have started using a third type of steam cooling system called dry cooling. Instead of using water to lower cooling water temperature, these systems use air passed over the cooling water by one or more large fans. Running those fans can require a significant amount of electricity, which makes this system less suited for large plants that require a lot of steam such as those powered by coal or nuclear energy. [11]

Three Integrated Cooling Systems

The illustration below is a simplified look at the main cooling loops in the Davis-Besse nuclear power station in Ohio. It features a pressurized water reactor in which uranium fuel is in long metal fuel rods (1) leading down to the reactor core (2). The reactor core is inside the reactor vessel (3) which is filled with purified water. Control rods (4) on top of the reactor start and stop the chain reaction that produces heat. When the rods are withdrawn, the nuclear chain reaction occurs, producing heat.

Figure 7. The Three Main Cooling Loops in a Nuclear Power Plant. [12]

Figure 7. The Three Main Cooling Loops in a Nuclear Power Plant. [12]

The water inside the Davis-Bessie PWR is under pressure so it won’t boil as its temperature rises by passing through the nuclear core. The water then travels along tubes through the steam generator (5) and back to the reactor. This constitutes the primary loop (green). After it has passed through the steam generator, the water has cooled down. The average temperature in this cycle is maintained at 582°F.

When the primary coolant water passes through the steam generator, its heat is transferred to the secondary loop (blue). Heat is transferred without the water in the primary loop and secondary loop ever coming in contact with each other. The water in the secondary loop boils to steam in the steam generator. This steam flows to the turbine generator (6). It is here that the steam’s energy is made into electricity.

When the steam leaves the turbine, it comes in contact with pipes carrying cooling water. As the steam cools, it changes back into water. The third loop (yellow) contains the water that is cooled by the large cooling tower (7). [12]

Among all of the power plants in the US, just over half reuse their cooling water. The rest are either dry systems or hybrid systems which can switch between dry and some sort of wet cooling depending on the temperature and availability of water.

References:
[1] Bright Hub Engineering, http://www.brighthubengineering.com/power-plants/2722-components-of-nuclear-power-plant-coolant/
[2, 3] http://www.world-nuclear.org/information-library/nuclear-fuel-cycle/nuclear-power-reactors/nuclear-power-reactors.aspx
[4] https://en.wikipedia.org/wiki/Nuclear_reactor_core
[5] https://commons.wikimedia.org/wiki/File:The_pressurized_water_reactor_of_NS_Savannah.jpg
[6] Nuclear Energy Institute, http://www.nei.org/Knowledge-Center/Nuclear-Fuel-Processes
[7] http://energy.gov/sites/prod/files/2014/01/f7/csp_review_meeting_042313_martin.pdf
[8] Vallourec, http://www.vallourec.com/NUCLEARPOWER/EN/products/nuclear-island/Pages/crdm.aspx
[9] http://cdn.intechopen.com/pdfs-wm/14150.pdf
[10] Union of Concerned Scientists, http://www.ucsusa.org/clean_energy/our-energy-choices/energy-and-water-use/water-energy-electricity-cooling-power-plant.html#.V8i9Cs9ATct
[11] https://en.wikipedia.org/wiki/Pressurized_water_reactor
[12] http://www.co.ottawa.oh.us/ottawacoema/davisbesse.html

Case Study: Thermal Management in Harvard Medical School Tissue Analysis Instrumentation

Designers of today’s highly advanced medical diagnostic equipment must overcome many of the same thermal challenges common to telecommunications, industrial and information technology electronics.

In addition, medical diagnostic devices present unique design issues and boundary conditions that factor into thermal solutions. These include isothermal and cyclic temperature demands, precise test repeatability, and maintaining the patient’s safety and comfort.

These kinds of issues were presented by Harvard Medical School to the experts at Advanced Thermal Solutions, Inc. (ATS) when it needed a cooling solution for the diagnostic equipment it was relying on for the analysis and observation of human tissue samples in a controlled laboratory setting. This was the school’s Frozen Tissue Microarrayer System.

ATS engineers had to provide thermal solutions to meet a range of design goals:

• Provide long-term temperature control for tissue samples embedded in an optimum cutting temperature fluid.
• Create a cooling system to maintain tissue samples below -70°C for six hours.
• Ensure operator visibility of the samples.
• Eliminate humidity and frost within the system to prevent sample contamination.

ATS Cooling Solutions

ATS engineers developed highly effective thermal solutions to meet all the design requirements of the diagnostic equipment. A reservoir in the device holds the liquid cooling medium and tissue samples are loaded through an opening at the top. Through a duct, cool air is circulated over the top of the samples to maintain temperature and humidity requirements.

As seen in Fig. 1 (below), the diagnostic system consisted of:

• Frozen tissue coring machine (on the right in the photo)
• Tissue sample loading area at the top of the cooling system (seen on the left)
• Duct system (on both sides of system) to circulate cool air
• Ice/alcohol reservoir at the system’s bottom to contain the cooling medium

Harvard Case Study

Figure 1. Prototype system created by ATS engineers for Harvard Medical School laboratory. (Advanced Thermal Solutions, Inc.)

Conduction Cooling Design

In operation, tissue samples are loaded into removable aluminum cassettes that fit tightly into a metal receiver (top left, Figure 2). The receiver contacts the cassette on five sides which allows for cooling of the samples by conduction. The receiver is lowered into a reservoir containing a slurry of dry ice and ethyl alcohol. Here the receiver is maintained at a constant temperature until the dry ice evaporates. The reservoir is double-walled and insulated to extend the evaporation time of the dry ice.

The receiver also features integral fins that increase surface area for drawing heat downward from the base of the cassettes into the icy slurry (bottom left, Figure 2). These fins are based on the same ATS heat sink design principles used in the company’s high performance maxiFLOW™ heat sinks.

Using analytical modeling, ATS engineers determined that 10 fins were the optimal number for cooling the cassette receiver and its contents. CFD simulations also showed that the 10-fin concept resulted in an optimal design. The engineers validated their analytical and CFD results through empirical testing. It was determined that extending 10 fins into the slurry provided the cooling performance to maintain tissue sample temperatures below the -70°C threshold for 9.75 hours.

Further temperature testing using thermocouples showed only a 2.5°C difference between the coldest points at the bottom of the fins and the tissue samples in the cassette. This proved that the design overcame thermal conduction resistance and could effectively maintain the samples below their critical temperature.

Figure 2. Temperature testing with thermocouples demonstrated that the temperature difference between the bottom of the fins and the top of the cassette, through three intervening layers, was only 2.5°C. This proved that the thermal design was successful. (ATS)

Figure 2. Temperature testing with thermocouples demonstrated that the temperature difference between the bottom of the fins and the top of the cassette, through three intervening layers, was only 2.5°C. This proved that the thermal design was successful. (ATS)

Figure 3. Using a heat sink-specific thermal resistance network ATS determined that the optimal number of fins was 10. (ATS)

Figure 3. Using a heat sink-specific thermal resistance network ATS determined that the optimal number of fins was 10. (ATS)

Convection Cooling Design

The above conduction cooling design provided only part of the solution. There were additional needs to maintain the temperature at the top of the samples and to decrease the relative humidity of the cool air from the ambient air in the lab. ATS engineers designed a convection cooling system to fulfill these requirements.

A heat exchanger was installed with its fins in the dry ice/alcohol slurry and its other side extending into a duct to cool the air passing over it. This approach uses the same cooling medium for both convection and conduction to ensure there is no temperature differential throughout the sample and that the sample is as isothermal as possible.

Air is pushed by a counter-rotating fan through the duct and into the heat exchanger. The heat exchanger forms a thermal link between this air and the slurry mixture. The heat exchanger was designed with an optimum balance between its surface area and the resulting pressure drop to ensure the fan was operating with the most effectiveness.

Once the air passes the heat exchanger, it moves through the ducts and into a diffuser at the top of the system. The diffuser disperses the air over the sample creating a barrier between the tissue and the ambient environment of the lab so outside moisture and heat are not transferred in.

The ATS engineers tested this design using an array of thermocouples and ATS hotwire anemometer Candlestick Sensors connected to an ATS ATVS-2020, a temperature and air velocity scanner. They determined there was too much mixing between the air flowing over the samples and ambient air. The diffuser was redesigned with a new connection to the duct and an optimized outlet radius (see Figure 4).

In the ducts, a molecular sieve desiccant housed in a honeycomb structure was used to reduce the dew point of the air to -84.4°C, which was well below the -72°C air temperature in the duct.

Figure 4. Initial testing led to a redesign of the air diffuser to prevent ambient humidity from mixing with the air over the tissue samples. (ATS)

Figure 4. Initial testing led to a redesign of the air diffuser to prevent ambient humidity from mixing with the air over the tissue samples. (ATS)

Conclusions

ATS engineers performed a final series of tests of the Frozen Tissue Microarrayer System using Candlestick Sensors, thermocouples and the ATVS 2020 scanner. The tissue temperature stayed constant over the required six-hour period and well below the -70°C threshold. In fact, testing determined that the tissue temperature remained below the threshold for nearly eight hours before warming above a usable temperature (Figure 5). The multi-part cooling system was a success, meeting the original design objectives provided by Harvard Medical School.

Figure 5. Final testing showed that the ATS cooling design kept tissue temperature (shown in blue in the graph above) below the -70°C threshold for more than the required six hours. (ATS)

Figure 5. Final testing showed that the ATS cooling design kept tissue temperature (shown in blue in the graph above) below the -70°C threshold for more than the required six hours. (ATS)

The process of designing cooling solutions for the Frozen Tissue Microarrayer demonstrated that thermal design practices used throughout electronics cooling can be applied in the medical device industry. Fin efficiency, thermal resistance, and pressure drop calculations are standard regardless of the application. Thermal solutions should be considered early in the design process so they can be incorporated into the overall system as efficiently as possible.

The experts at ATS used traditional thermal calculations, CFD simulations, empirical testing, and its leading-edge heat sink technology to successfully design the thermal solution for this medical equipment application. The ATS design allowed Harvard Medical School to test tissue samples while meeting its strict requirements.

To learn more about the design, watch the video below:

Download a PDF of this case study at http://www.qats.com/cms/wp-content/uploads/Harvard-Medical-case-study.pdf.

Visit www.qats.com, call 781-769-2800 or email [email protected] to learn more about ATS and its Thermal Management Analysis and Design Services.